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Sanatan Upmanyu

Work.

Production AI systems and commercial products I’ve built or led — spanning target discovery, clinical-trial intelligence, digital twins, regulatory automation, and portfolio decisions. Stages reflect where each sits today; all continue to evolve.

Selected work

  • AlphaMeld® Operating System

    Live
    alphameld.com
    Compresses hypothesis-to-insight cycles from months to weeks, varying by disease area

    End-to-end AI stack combining a custom UI layer (Knowledge Graph, ChatAlphaMeld, Bioinformatics, Literature Analysis, AlphaClinMeld) with 12 ML models — including NER, RE, evidence scoring, digital-twin CT predictors and landscape assessment — running on PostgreSQL + Neo4j and self-hosted GPT/Claude custom APIs.

  • Discovery Navigator

    Early access
    discovery.alphameld.com
    Hypothesis landscaping compressed from weeks to hours, with traceable evidence at every step

    Guided drug-discovery hypothesis-generation platform built on the AlphaMeld Knowledge Graph. Supports four starting points — disease-first, target-first, indication expansion, and combination therapy — through a step-by-step workflow (project → config → exploration → agent scoring → ranking → hypotheses). A project-aware Discovery Copilot accompanies every step. Multi-tenant SaaS with SSO, RBAC, and audit logging.

  • ChatAlphaMeld Benchmark Suite

    Research
    inveniai.com
    97.34% accuracy on 188-question ACM benchmark

    Two agentic workflow engines fine-tuned on biomedical tasks; outperformed GPT-4o, GPT-4o-mini, and o3-mini variants; delivered richer step-by-step rationales critical for complex clinical questions.

  • SequenceFlow® ResearchNexus & Clinical Navigator

    Live
    6+ integrated modules

    End-to-end AI stack combining Knowledge Graph, Clinical Trial Prediction, Literature Analysis, Patient Digital Twin, TPP, TOP with 12 ML models running on PostgreSQL + Neo4j and self-hosted GPT/Claude custom APIs.

  • AlphaCompass Portfolio Intelligence

    Live
    Standardized indication-prioritization across 200 active programs

    Clinical-trial–centric SaaS module on AlphaMeld® graph analytics; benchmarks pipeline assets and quantifies comparative risk. Adopted by two BD teams within six months, standardizing evidence-based indication-prioritization across 200 active programs.

  • Clinical-Trial Digital Twins

    Research
    In-silico placebo arms demonstrated for Phase II Type 2 Diabetes trials

    Conditional variational auto-encoder (CVAE) pipeline that synthesizes patient-level digital twins for Phase II Type 2 Diabetes trials. Generated matched placebo trajectories and predicted drug-response curves — proving feasibility of in-silico arms for protocol optimization and hypothesis testing.

  • Pipeline Alpha

    Live
    pipelinealpha.com
    Tracks ~10,000 clinical-trial drugs and AI-predicts the catalysts that move small-cap biotech stocks

    Investment research platform for small/mid-cap NASDAQ biotechs where a single trial readout can move the stock 50%+. Syncs clinical-trial data (ClinicalTrials.gov, Clinical Navigator) with live stock and financials (Alpha Vantage), then runs LLM catalyst discovery and streaming AI predictions for upcoming readouts, PDUFA dates, partnerships, and conference events. Includes bulk catalyst briefings and an interactive research chat.

  • QuriousRI

    Live
    app.quriousri.com
    Built for Artixio Pvt Ltd
    Drug & biologic regulatory intelligence spanning 12+ agencies — FDA, EMA, PMDA, NMPA, Health Canada, MHRA, Swissmedic, and more

    Secure, role-based platform for pharma/biotech regulatory affairs teams to search, analyze, compare, and manage global drug and biologic approvals. Covers pharmaceuticals, biologics, biosimilars, and generics across 12+ regulators. Combines role-based dashboards, pathway and classification guides, dossier preparation support, a centralized guidelines library, Q&A with expert responses, and AI-assisted document analysis (GPT-4, Claude).

  • Secondary Research Automation

    Engagement
    Agent-orchestrated multi-step research, delivered to dashboard or Excel

    Fully agent-orchestrated, multi-step LLM process. Input parameters, run a series of LLM processes to extract information from the web, compile, and store in a dashboard or export to Excel.

  • Booking System Platform

    Engagement
    Bespoke booking platform delivered end-to-end to client spec

    End-to-end booking and scheduling platform — custom-built to client specification with real-time availability, notifications, and management dashboard.

  • Regulatory Intelligence for ArtiXio

    Live
    Auto-drafts submission dossiers for first-in-class device filings; opened a new non-pharma revenue channel

    AI assistant that mines global regulatory updates and auto-drafts submission dossiers; established a new non-pharma revenue channel.

What I help with

AI & Data Science

  • GenAI & LLM-RAG Systems
  • Agentic AI Workflows
  • Predictive Modeling & Image Analysis
  • Knowledge Graphs & NLP

Scientific Computing & Infrastructure

  • Cloud & HPC Architecture
  • Data Pipeline Engineering
  • Full-Stack Platform Development
  • Digital Twin Modeling

Life Sciences & Drug Discovery

  • Target Validation & MOA Analysis
  • Clinical Trial Optimization
  • Regulatory Intelligence
  • Drug Repurposing & Portfolio Strategy

Leadership & Strategic Consulting

  • Team Building & Mentorship
  • Partner & Client Engagement
  • Product Vision & Agile Delivery
  • Speaking & Thought Leadership
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